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SUMMARY:μSR studies of dynamics in model biomembranes
DTSTART;VALUE=DATE-TIME:20220830T164000Z
DTEND;VALUE=DATE-TIME:20220830T170000Z
DTSTAMP;VALUE=DATE-TIME:20220826T121245Z
UID:indico-contribution-3724@indico.stfc.ac.uk
DESCRIPTION:Speakers: Iain McKenzie (TRIUMF)\nAvoided level crossing muon 
 spin resonance (ALC-$\\mu$SR) has been used to study the dynamics of the a
 lkyl chains and cholesterol within model biomembranes composed of phosphol
 ipids (DPPC and POPC) and cholesterol. ALC-$\\mu$SR is sensitive to motion
 s on timescales between that measurable by NMR and neutron scattering. Muo
 nium adds to the unsaturated C=C bonds of POPC and cholesterol to give in 
 situ spin probes.  The muon and methylene proton hyperfine coupling consta
 nts (hfccs) were determined from the $\\Delta_1$ and $\\Delta_0$ resonance
  fields in the ALC-$\\mu$SR spectra. The dipolar muon hfccs ($D_{\\mu}^{\\
 parallel}$) and the electron spin flip rates were determined by modelling 
 the $\\Delta_1$ and $\\Delta_0$ resonance lineshapes using Monte Carlo sim
 ulations. These parameters provide information about the motion of the spi
 n probes in the alkyl chains. In all cases\, the spin probes are undergoin
 g restricted reorientational motion\, but the addition of cholesterol lead
 s to more restricted motion of the alkyl chains\, evident from the larger 
 $D_{\\mu}^{\\parallel}$\, and tighter packing of the chains\, which is ded
 uced from the magnitude of the muon hfccs. The goal of this project is to 
 determine how the dynamics at different positions within the biomembrane d
 epend on the composition.\n\nhttps://indico.stfc.ac.uk/event/53/contributi
 ons/3724/
LOCATION:Science and Technology Campus\, University of Parma
URL:https://indico.stfc.ac.uk/event/53/contributions/3724/
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